Ppt odontogenic cysts and tumors powerpoint presentation. Cyst development requires the presence of epithelium in deep tissues and a proliferative stimulus. Keratocystic odontogenic tumor was described first time by philipsen in 1956 as an odontogenic cyst. Factors such as inflammation or trauma stimulate epithelial rests to proliferate sealing off the. Comparison of components of odontogenic cyst fluids. The human homologue of drosophila patched gene ptch, located at 9q22. A radicular cyst is an odontogenic cyst of inflammatory origin i abstract.
A free powerpoint ppt presentation displayed as a flash slide show on id. However, epithelial rests may be the origin for the cyst lining later. Review of the molecular pathogenesis of the odontogenic. Recently, due to aggressive behavior and tendency to high recurrence of these lesions, the new classification of who placed it in the category of the benign. Having been classified as a cyst of odontogenic origin for over five decades, the pathogenesis, histological character and progress of the entity finally led to the metamorphosis from a cyst to an odontogenic tumour in 2005. Ameloblastoma, squamous odontogenic tumour, calcifying epithelial odontogenic tumour and adenomatoid odontogenic tumour. Cysts and odontogenic neoplasms 162 apical cyst periapical cyst radicular cyst, root end cyst epithelial lined jaw cyst found as radiolucencies at the end of roots of nonvital teeth. This obviously requires a compliant and dextrous patient who would be able to maintain hygiene. Radicular cysts are the most common of all jaw cysts and comprise about 52% to 68% of all the cysts affecting the human jaws. Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. The role of endotoxin and cytokines in the pathogenesis of. These mucous, ciliated and sebaceous elements are postulated to represent the multipotentiality of the odontogenic epithelial lining in a dentigerous cyst. Adenomatoid odontogenic tumor, complex odontome, dentigerous cyst, mucoepidermoid carcinoma how to cite this article. Ptch expression in odontogenic cysts, a cause of pathogenesis or reason for clinical complication.
The odontogenic keratocyst okc is a recurrent cyst that has been recently reclassified from an odontogenic tumor to an odontogenic cyst. Nonneoplastic proliferative lesions may also demonstrate high expression of some proliferative markers. Odontogenesis, odontogenic cysts, and odontogenic tumors. These are individual lesions which arise from the same odontogenic apparatus but with varying pathogenesis. Most are discovered on routine radiographs, when a tooth has failed to erupt, a tooth is missing, teeth are tilted or are otherwise out of alignment. Keratocyst endotoxins and cytokines in odontogenic cysts radicular cyst follicular cyst 527 fig. Performing routine radiograph is of high clinical value, especially before orthodontic treatment. The use of new molecular tools and their potential contribution to the understanding of. Review article pathogenesis and nomenclature of odontogenic carcinomas. Radicular cyst an update with emphasis on pathogenesis. This study was aimed to evaluate and compare the density of mast cells in dentigerous cyst dc and keratocystic odontogenic tumor kcot regarding their different clinical behavior. Department of oral pathology, university of birmingham, england.
Odontogenic cysts and tumors michael underbrink, md anna pou, md february, 2002 introduction variety of cysts and tumors uniquely derived from tissues of. The cyst histology is exactly the same as the lateral periodontasl cyst see above, except that its in the gingiva and not in bone. The following classification system is a modification of the world health organization. Review article pathogenesis and nomenclature of odontogenic.
Ameloblastoma, squamous odontogenic tumour, calcifying. Depending on the histologic diagnosis, the patient may 1 require no further treatment other than the simple enucleation of the cyst already. The dentigerous cyst arises from pooling of inflammatory exudate, which is derived from the obstructed follicular veins of an unerupted tooth and accumulates. Research article the possible role of mast cells in the. An odontogenic cyst is a pathological, epitheliallined cavity containing fluid or semifluid which arises from the epithelial remnants of tooth formation. Dentigerous cyst is the most common developmental odontogenic cyst with excellent prognosis and low recurrence. Radicular cyst is an inflammatory odontogenic cyst of the jaws which is most commonly seen along with necrotic pulp of the tooth following inflammatory reaction due to physical, bacterial or chemical injury. The pathogenesis of dental cysts can usually be described as a consequence of and as originating from remnants of the complicated process of embryonal tooth and jaw development. Radiology of cysts of the jaws columbia university. Revisited swagatikapanda, 1 sujitranjansahoo, 1 gunjansrivastav, 2 subratpadhiary, 3 kanikasinghdhull, 4 andsoniaaggarwal 5 department of oral pathology and microbiology, institute of dental sciences, kalinga nagar, bhubaneswar, india.
May protrude into cyst lumen or extend into underlying connective tissue wall identical to structures present in lateral periodontal cysts or botryoid odontogenic cysts or soft tissue odontogenic cyst, gingival cyst of adult. Dentigerous cyst is the second most prevalent type of odontogenic cysts after radicular cyst. The possible role of mast cells in the odontogenic cysts. Stanford medicine school of medicine departments surgical pathology criteria odontogenic jaw cysts. It most often affects the posterior mandible and most commonly presents in the third decade of life. Microscopically, the lesion is similar to the lateral periodontal cyst but exhibits some differences. The exact pathogenesis of dentigerous cyst is unknown. The glandular odontogenic cyst goc is an uncommon cyst of the jaws, locally aggressive and with recurring potential 1 kramer irh, pindborg jj, shear m, eds. Also called as odontogenic ghost cell cyst or gorlin cyst. Odontogenic cysts ioannis chatzistefanou, vassilios kogias and.
The book emphasizes investigative pathology of odontogenic cysts and uses numerous illustrations and tables to reinforce and summarize discussions presented in the text. Cystic degeneration of deep projections of surface epithelium. Odontogenic cysts are distinct entities and quite a common occurrence in the jaw bones. Cyst formation, like the development of neoplasms, involves a dysregulation of the balance between cell proliferation and cell death. The possible role of mast cells in the odontogenic cyst s pathogenesis. Ptch expression in odontogenic cysts, a cause of pathogenesis or reason for clinical complication article pdf available in oral oncology extra 4110. Reclassification and treatment of odontogenic keratocysts. The books most important aspect is its attempt to bring together new information regarding odontogenesis and the pathogenesis of odontogenic cysts.
Glandular odontogenic cyst not all expert agree that this is a variant of the lateral periodontal cyst, especially because of its. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. It appears mostly in young patients and females, the maxillary. Mar 21, 2017 botryoid odontogenic cyst it is a variant of lateral odontogenic cyst, but that the term botryoid odontogenic cyst should be retained because of the tendency of this variant to recur if inadequately removed. Radicular cysts arise from the epithelial residues in the. Patient usually comes with a concern of delayed tooth eruption or facial swelling.
Since its initial description, a number of studies have focused on different aspects of this lesion, attempting to explain its distinctive biological behaviour. The pathogenesis of this rare group remains still controversial and there have been many varied opinions over the classification of this rare group of lesions. Agarose gel of the rtpcr products showing mrna for all three cytokines illet, 1 and 6 from a keratocyst, radicular cyst and follicular cyst. Inflammatory odontogenic cysts 1 radicular cyst see od1 notes cyst at apex or around root of a nonvital tooth. Intrabony cysts are most common in the jaws, because the mandible and maxilla are the only bones with epithelial. This decompression facilitates a reduction in the size of the cyst and so, at a later an odontogenic cyst is a pathological. The authors conducted a search in english literature using the following keywords. Sep 09, 2014 diagram of odontogenic cysts based on clinical and radiographic features 10. A molecular insight into the role of inflammation in the behavior and. Induced proliferation of epithelial cell rests rests of serres or malassez in the jaw region plays an important role in the pathogenesis of odontogenic cysts. The pathogenesis of the three common forrns of odontogenic cyst is discussed. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions.
The glandular odontogenic cyst is usually asymptomatic and involves the mandible more often than the maxilla. Odontogenic cyst are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development. Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium. Has many features of odontogenic tumor, therefore it is placed in the category of tumors in the latest who classification of odontogenic cysts and tumors. They are most commonly seen in maxillary anterior region. It enlarges by unicentric expansion from the hydrostatic pressure of its contents. One or several areas of nodular thickening may be seen on the luminal surface in the gross examination of the fibrous wall of a dentigerous cyst. Radicular cysts arise from the epithelial residues in the periodontal ligament as a result of inflammation. Review of molecular pathogenesis of odontogenic keratocyst. Botryoid odontogenic cyst it is a variant of lateral odontogenic cyst, but that the term botryoid odontogenic cyst should be retained because of the tendency of this variant to recur if inadequately removed. Review of literature and report of a new case with cytokeratin19 expression marco mascitti 1, andrea santarelli 1, 2, antonio sabatucci 1, maurizio procaccini 1, 2, lorenzo lo muzio 3, antonio zizzi 4, corrado rubini 4.
Comparable changes do not occur in any other region of the body. This study was conducted on 23 and 26 cases of dc and kcot, respectively. Pathogenesis and nomenclature of odontogenic carcinomas. Role of cytokeratin7 in the pathogenesis of odontogenic. That odontogenic epithelium is critical in normal tooth development. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tooth. The aim of the present study was to investigate its treatment and address. Emphasis is placed on pathogenesis and clinicopathologic features of these lesions. Abstract adenomatoid odontogenic tumour a relatively rare neoplasm constitutes about 27% of odontogenic cysts and tumours combined. Calcifying odontogenic cyst calcifying ghost cell odontogenic cyst, calcifying cystic odontogenic tumor about 1% of cysts. Pdf ptch expression in odontogenic cysts, a cause of. Odontogenic keratocyst and keratocystic odontogenic tumour.
The opening can also be maintained with packing material or a prosthetic bung. Also known as the tumour of the 23rd due to its clinical and radiographic features. Odontogenic cysts are largely classified based on their location, viability of the associated tooth and clinical setting. The odontogenic keratocyst keratocystic odontogenic tumour okc is one of the most prevalent odontogenic tumours. Multiple cystic spaces similar to those seen in botryoid odontogenic cysts. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin.
Odontogenic cysts, tumors, and related jaw lesions preceptor. Dec 22, 2016 cysts are frequent lesions occurring in the oral cavity and are of much significance because they may be destructive and cause significant signs and symptoms. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tootli. Odontogenic keratocysts make up around 19% of jaw cysts. The most common developmental odontogenic cyst is the dentigerous cyst. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. The cyst encloses the crown of an unerupted tooth by the expansion of its follicle due to a collection of cystic fluid. The pathogenesis of the three common forms of odontogenic cyst is discussed. Paradental cyst is an inclusion cyst of the junctionalsulcular epithelium of the gingiva. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst.
For example, mucous cyst of the oral mucosa and nasolabial duct cyst are not of odontogenic origin. Hyperchromatic, cuboidal or columnar basal cell layer 3. Diagnosing the most common odontogenic cystic and osseous. Cysts are frequent lesions occurring in the oral cavity and are of much significance because they may be destructive and cause significant signs. Pathogenesis of odontogenic cysts cyst formation in the jaws requires three elements. Cytokeratins are integral components in tooth development and are expressed across the odontogenic tissues in physiological and pathological states. Dentigerous cyst a follicular cyst, or dentigerous cyst is a developmental odontogenic cyst which develops around the fullyformed crown of an unerupted tooth. For each tooth, odontogenesis table 3 begins with the formation. Intricate pathogenesis of radicular cyst international. The pathogenesis for the development and expansion of cysts is often debated and the authors aim to give a brief outline of this. Initiation inflammatory cysts infection other cysts dental lamina enamel organ reduced enamel epithelium cell rests of malassez 12. Three major types of odontogenic cyst are recognizable on the basis of their epithelial derivation, dental relation. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst.