Stanford medicine school of medicine departments surgical pathology criteria odontogenic jaw cysts. Glandular odontogenic cyst not all expert agree that this is a variant of the lateral periodontal cyst, especially because of its. Also called as odontogenic ghost cell cyst or gorlin cyst. Since its initial description, a number of studies have focused on different aspects of this lesion, attempting to explain its distinctive biological behaviour. It appears mostly in young patients and females, the maxillary. Performing routine radiograph is of high clinical value, especially before orthodontic treatment. Hyperchromatic, cuboidal or columnar basal cell layer 3.
Radicular cysts are the most common of all jaw cysts and comprise about 52% to 68% of all the cysts affecting the human jaws. The cyst encloses the crown of an unerupted tooth by the expansion of its follicle due to a collection of cystic fluid. Ameloblastoma, squamous odontogenic tumour, calcifying epithelial odontogenic tumour and adenomatoid odontogenic tumour. Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. Odontogenic cysts are distinct entities and quite a common occurrence in the jaw bones. Odontogenic keratocyst and keratocystic odontogenic tumour. The possible role of mast cells in the odontogenic cyst s pathogenesis. An odontogenic cyst is a pathological, epitheliallined cavity containing fluid or semifluid which arises from the epithelial remnants of tooth formation. Review article pathogenesis and nomenclature of odontogenic. Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium. Radiology of cysts of the jaws columbia university. This study was aimed to evaluate and compare the density of mast cells in dentigerous cyst dc and keratocystic odontogenic tumor kcot regarding their different clinical behavior. This study was conducted on 23 and 26 cases of dc and kcot, respectively.
Review article pathogenesis and nomenclature of odontogenic carcinomas. The most common developmental odontogenic cyst is the dentigerous cyst. The human homologue of drosophila patched gene ptch, located at 9q22. Most are discovered on routine radiographs, when a tooth has failed to erupt, a tooth is missing, teeth are tilted or are otherwise out of alignment. Also known as the tumour of the 23rd due to its clinical and radiographic features. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Radicular cysts arise from the epithelial residues in the. The use of new molecular tools and their potential contribution to the understanding of. Cytokeratins are integral components in tooth development and are expressed across the odontogenic tissues in physiological and pathological states. Cysts are frequent lesions occurring in the oral cavity and are of much significance because they may be destructive and cause significant signs. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. The following classification system is a modification of the world health organization. Role of cytokeratin7 in the pathogenesis of odontogenic.
Depending on the histologic diagnosis, the patient may 1 require no further treatment other than the simple enucleation of the cyst already. The glandular odontogenic cyst is usually asymptomatic and involves the mandible more often than the maxilla. Odontogenic keratocysts make up around 19% of jaw cysts. The pathogenesis for the development and expansion of cysts is often debated and the authors aim to give a brief outline of this.
Inflammatory odontogenic cysts 1 radicular cyst see od1 notes cyst at apex or around root of a nonvital tooth. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. Keratocyst endotoxins and cytokines in odontogenic cysts radicular cyst follicular cyst 527 fig. Comparable changes do not occur in any other region of the body. Agarose gel of the rtpcr products showing mrna for all three cytokines illet, 1 and 6 from a keratocyst, radicular cyst and follicular cyst. A radicular cyst is an odontogenic cyst of inflammatory origin i abstract. Ptch expression in odontogenic cysts, a cause of pathogenesis or reason for clinical complication. The exact pathogenesis of dentigerous cyst is unknown. Paradental cyst is an inclusion cyst of the junctionalsulcular epithelium of the gingiva.
Research article the possible role of mast cells in the. Having been classified as a cyst of odontogenic origin for over five decades, the pathogenesis, histological character and progress of the entity finally led to the metamorphosis from a cyst to an odontogenic tumour in 2005. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. The opening can also be maintained with packing material or a prosthetic bung. Calcifying odontogenic cyst calcifying ghost cell odontogenic cyst, calcifying cystic odontogenic tumor about 1% of cysts. Dentigerous cyst a follicular cyst, or dentigerous cyst is a developmental odontogenic cyst which develops around the fullyformed crown of an unerupted tooth. Intrabony cysts are most common in the jaws, because the mandible and maxilla are the only bones with epithelial. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst. Intricate pathogenesis of radicular cyst international.
Botryoid odontogenic cyst it is a variant of lateral odontogenic cyst, but that the term botryoid odontogenic cyst should be retained because of the tendency of this variant to recur if inadequately removed. Radicular cyst an update with emphasis on pathogenesis. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tooth. Cysts and odontogenic neoplasms 162 apical cyst periapical cyst radicular cyst, root end cyst epithelial lined jaw cyst found as radiolucencies at the end of roots of nonvital teeth. The possible role of mast cells in the odontogenic cysts. The odontogenic keratocyst okc is a recurrent cyst that has been recently reclassified from an odontogenic tumor to an odontogenic cyst. One or several areas of nodular thickening may be seen on the luminal surface in the gross examination of the fibrous wall of a dentigerous cyst. This obviously requires a compliant and dextrous patient who would be able to maintain hygiene. Review of the molecular pathogenesis of the odontogenic keratocyst. Radicular cyst is an inflammatory odontogenic cyst of the jaws which is most commonly seen along with necrotic pulp of the tooth following inflammatory reaction due to physical, bacterial or chemical injury. Factors such as inflammation or trauma stimulate epithelial rests to proliferate sealing off the. Odontogenesis, odontogenic cysts, and odontogenic tumors.
Odontogenic cysts ioannis chatzistefanou, vassilios kogias and. Comparison of components of odontogenic cyst fluids. A molecular insight into the role of inflammation in the behavior and. Odontogenic cysts, tumors, and related jaw lesions preceptor. Odontogenic cyst are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development. The cyst histology is exactly the same as the lateral periodontasl cyst see above, except that its in the gingiva and not in bone. They are most commonly seen in maxillary anterior region.
Revisited swagatikapanda, 1 sujitranjansahoo, 1 gunjansrivastav, 2 subratpadhiary, 3 kanikasinghdhull, 4 andsoniaaggarwal 5 department of oral pathology and microbiology, institute of dental sciences, kalinga nagar, bhubaneswar, india. The book emphasizes investigative pathology of odontogenic cysts and uses numerous illustrations and tables to reinforce and summarize discussions presented in the text. Recently, due to aggressive behavior and tendency to high recurrence of these lesions, the new classification of who placed it in the category of the benign. Odontogenic cysts and tumors michael underbrink, md anna pou, md february, 2002 introduction variety of cysts and tumors uniquely derived from tissues of. Has many features of odontogenic tumor, therefore it is placed in the category of tumors in the latest who classification of odontogenic cysts and tumors. Three major types of odontogenic cyst are recognizable on the basis of their epithelial derivation, dental relation. The authors conducted a search in english literature using the following keywords. Pathogenesis and nomenclature of odontogenic carcinomas. The glandular odontogenic cyst goc is an uncommon cyst of the jaws, locally aggressive and with recurring potential 1 kramer irh, pindborg jj, shear m, eds. Dec 22, 2016 cysts are frequent lesions occurring in the oral cavity and are of much significance because they may be destructive and cause significant signs and symptoms. Review of molecular pathogenesis of odontogenic keratocyst.
Induced proliferation of epithelial cell rests rests of serres or malassez in the jaw region plays an important role in the pathogenesis of odontogenic cysts. For example, mucous cyst of the oral mucosa and nasolabial duct cyst are not of odontogenic origin. It enlarges by unicentric expansion from the hydrostatic pressure of its contents. Longstanding chronic inflammation in a periapical granuloma secondary to pulpal necrosis stimulates epithelial proliferation. The pathogenesis of this rare group remains still controversial and there have been many varied opinions over the classification of this rare group of lesions. The enigma of kcot is centred on the lack of recognition about the true biologic nature of this condition. Ameloblastoma, squamous odontogenic tumour, calcifying. Odontogenic cysts are largely classified based on their location, viability of the associated tooth and clinical setting. Sep 09, 2014 diagram of odontogenic cysts based on clinical and radiographic features 10.
Dentigerous cyst is the most common developmental odontogenic cyst with excellent prognosis and low recurrence. A free powerpoint ppt presentation displayed as a flash slide show on id. These are individual lesions which arise from the same odontogenic apparatus but with varying pathogenesis. Ppt odontogenic cysts and tumors powerpoint presentation. The dentigerous cyst arises from pooling of inflammatory exudate, which is derived from the obstructed follicular veins of an unerupted tooth and accumulates.
Dentigerous cyst is the second most prevalent type of odontogenic cysts after radicular cyst. Pathogenesis of odontogenic cysts cyst formation in the jaws requires three elements. This decompression facilitates a reduction in the size of the cyst and so, at a later an odontogenic cyst is a pathological. Nonneoplastic proliferative lesions may also demonstrate high expression of some proliferative markers. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Cyst development requires the presence of epithelium in deep tissues and a proliferative stimulus. The aim of the present study was to investigate its treatment and address. Reclassification and treatment of odontogenic keratocysts. Radicular cysts arise from the epithelial residues in the periodontal ligament as a result of inflammation. It most often affects the posterior mandible and most commonly presents in the third decade of life. Abstract adenomatoid odontogenic tumour a relatively rare neoplasm constitutes about 27% of odontogenic cysts and tumours combined. Review of literature and report of a new case with cytokeratin19 expression marco mascitti 1, andrea santarelli 1, 2, antonio sabatucci 1, maurizio procaccini 1, 2, lorenzo lo muzio 3, antonio zizzi 4, corrado rubini 4. Cystic degeneration of deep projections of surface epithelium.
Microscopically, the lesion is similar to the lateral periodontal cyst but exhibits some differences. However, epithelial rests may be the origin for the cyst lining later. The pathogenesis of dental cysts can usually be described as a consequence of and as originating from remnants of the complicated process of embryonal tooth and jaw development. The role of endotoxin and cytokines in the pathogenesis of. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tootli. Keratocystic odontogenic tumor was described first time by philipsen in 1956 as an odontogenic cyst.
Ptch expression in odontogenic cysts, a cause of pathogenesis or reason for clinical complication article pdf available in oral oncology extra 4110. Multiple cystic spaces similar to those seen in botryoid odontogenic cysts. The books most important aspect is its attempt to bring together new information regarding odontogenesis and the pathogenesis of odontogenic cysts. Review of the molecular pathogenesis of the odontogenic. Cyst formation, like the development of neoplasms, involves a dysregulation of the balance between cell proliferation and cell death. Pdf ptch expression in odontogenic cysts, a cause of.
Patient usually comes with a concern of delayed tooth eruption or facial swelling. Diagnosing the most common odontogenic cystic and osseous. Emphasis is placed on pathogenesis and clinicopathologic features of these lesions. Initiation inflammatory cysts infection other cysts dental lamina enamel organ reduced enamel epithelium cell rests of malassez 12. Mar 21, 2017 botryoid odontogenic cyst it is a variant of lateral odontogenic cyst, but that the term botryoid odontogenic cyst should be retained because of the tendency of this variant to recur if inadequately removed. The pathogenesis of the three common forrns of odontogenic cyst is discussed.
May protrude into cyst lumen or extend into underlying connective tissue wall identical to structures present in lateral periodontal cysts or botryoid odontogenic cysts or soft tissue odontogenic cyst, gingival cyst of adult. Adenomatoid odontogenic tumor, complex odontome, dentigerous cyst, mucoepidermoid carcinoma how to cite this article. The odontogenic keratocyst keratocystic odontogenic tumour okc is one of the most prevalent odontogenic tumours. For each tooth, odontogenesis table 3 begins with the formation. Department of oral pathology, university of birmingham, england. That odontogenic epithelium is critical in normal tooth development. These mucous, ciliated and sebaceous elements are postulated to represent the multipotentiality of the odontogenic epithelial lining in a dentigerous cyst. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. The pathogenesis of the three common forms of odontogenic cyst is discussed.